wo high school students from Earth, Doyle Cleverlobe and Aimee Brightower, didn't know what to expect when they were chosen to attend Galaxy High School, a place of learning for beings from all over the galaxy. The school was located on the asteroid Flutor, and provided an education for a truly diverse student body, ranging from individuals who somewhat resembled humans to others that looked like nothing more than a gob of goo.

Although Doyle was a star athlete who had been popular back on Earth, he had a tough time fitting in at Galaxy High. His usual charm and self confidence seemed to do him no good. To make matters worse, when he arrived at the school he was informed that because his grades were so terrible he would have to work part time at Luigi's Lunar Pizza Parlor – a popular hangout for the high school crowd – to help pay for his tuition. One of the few friends Doyle was initially able to make was class president Milo De Venus, who also worked at the pizza parlor. Milo resembled a human but had six arms, which he put to good use making pizzas at lightening speed when he wasn’t helping Doyle wait tables.

Aimee's experience in her new surroundings was more positive than Doyle's. On Earth Aimee had been the smartest girl in school, but her popularity suffered. At Galaxy High she learned that her grades had earned her a full scholarship as well as a new car (space vehicle), and she gained a close group of friends in no time. Her closest friends were Booey Bubblehead, a clear-headed girl (because her head was empty) who had a tough time staying focused or remembering what was happening; Gilda Gossip had four tentacles extending from the top of her head that each had a mouth attached, all of them taking turns spilling the latest gossip; and Wendy Garbo was a fashionable girl with an eye for the boys. Aimee was closely followed everywhere by The Creep, a little, yellow flying ball of fur (or maybe he was covered in feathers) who got his name because of the obsessive crushes he developed for the female students.

Doyle quickly got on the bad side of the school bully, Beef Bonk, and his two friends, Rotten Ronald (who liked to toss rotten eggs) and Earl Eccchhh (a sentient pile of ooze). Beef was big, strong, had a bad temper and took every opportunity to give Doyle grief. He even wore a shirt with the phrase "Earth Stinks!!" to show how much he hated Earth boys. Things may not have been so bad for Doyle if he hadn't felt the need to constantly get even with Beef, pulling pranks that just earned him additional attention from the Bonk Bunch.

A few other notable characters were homeroom teacher Ms. McBrain, who had what looked like a light bulb attached to the back of her head that lit up when she got an idea; Professor Icenstein came from the planet Froster and had to keep his classroom at a freezing temperature or he would melt; Coach Frogface thought flies were tasty; female gym teacher Katrina resembled a centaur; and the reliable taxi driver Ollie Oilslick was available when the kids needed a ride.